BedWetting Desipramine Breast cancer

BedWetting Desipramine Breast cancer

BedWetting Desipramine Breast cancer

There are studies which have given the following results –BedWetting Desipramine Breast cancer

  • Desipramine is proven to be genotoxic in fruit flies and is considered to result in increase of breast cancer cases in women.
  • There is high  likelihood of overdose of Desipramine (both accidental and intentional).
  • Desipramine should be considered carefully by the prescribing physician prior to patient use.
  • Symptoms of overdose are similar to those of other tricyclic antidepressants, with cardiac toxicity (due to inhibition of sodium and calcium channels) generally occurring before the threshold for serotonin syndrome is reached.
  • Due to this risk, tricyclic antidepressants are rarely selected as the first line treatment for depression. Desipramine overdose should always be considered a medical emergency. In the event of a suspected or known overdose, a poison control center

Bed Wetting-desipramine-Norpramin

Bed Wetting-desipramine-Norpramin

  • In 1993 4 children died who were taking Norpramin.  3 more children were reported to have died in the next issue of the Journal.
  • In 1992, there were 4.6 million prescriptions for desipramine for children 18 and under, according to National Institute of Mental Health data.
  • At that time FDA said that they are aware of the reports of the four sudden deaths and that they are monitoring the situation.
  • FDA also said that the drug is not recommended for use in children and there are two warnings on the label to that effect.
  • People must make an attempt to know what is happening after 20 years from the date of publishing of this report.
  • The new safety information states that extreme caution should be used when this drug is given to patients who have a family history of sudden death, cardiac dysrhythmias, and cardiac conduction disturbances,” according to an alert sent from MedWatch, the FDA’s safety information and adverse event reporting program.The FDA and the manufacturer also warn that some patients may have seizures before cardiac dysrhythmias and death. Desipramine overdose is more likely to result in death than overdose with other tricyclic antidepressants, notes a company letter sent to healthcare professionals.

After 20 years of monitoring the deaths from the drugs, the FDA is thinking of changing the warning labels of the medicines

  • On December 2, 2009, FDA warned healthcare professionals to use caution when prescribing the antidepressant desipramine hydrochloride (Norpramin) in patients with a family history of dysrhythmias or sudden cardiac death.
  • “The new safety information states that extreme caution should be used when this drug is given to patients who have a family history of sudden death, cardiac dysrhythmias, and cardiac conduction disturbances,” according to an alert sent today from MedWatch, the FDA’s safety information and adverse event reporting program.
  • The FDA and the manufacturer also warn that some patients may have seizures before cardiac dysrhythmias and death. Desipramine overdose is more likely to result in death than overdose with other tricyclic antidepressants, notes a company letter sent to healthcare professionals.
  • The “warnings” and “overdosage” sections of the drug’s labeling are being changed to reflect these potential adverse events.

Bed Wetting medicine DesmoMelt Kills

Bed Wetting medicine DesmoMelt Kills

Samuel Boon A boy who died on Morocco trek was ‘taking bed-wetting medication. This was reported in 2014.

Bed Wetting medicine DesmoMelt Kills – Why no corrective steps are taken by the government to stop these medicines. Are the governments all over the world playing in the hands of the pharma companies.

Bed wetting killer Medicines

Bed Wetting medicine DesmoMelt Kills
Bed Wetting medicine DesmoMelt Kills

Fluid imbalance is most important factor for rest of the life – Quality of life.

Bed wetting is the first indication of poor Quality of life.

Parents would be interested to do anything to stop bed wetting.

And the most important is that it is easy to cure. This will reduce the govt spend on health care in any country by 80% of annual health care costs in 10 years time.

 

Desmopressin

Desmopressin

Desmopressin side effects are very serious. There are conflicting claims about this medicine. Desmopressin deals with ADH, which the other more credible web sites say is not the reason / cause for bed wetting.

Desmopressin

There is a reasonble ground for suing the pharma companies for causing irrepairable damage to the children with this medicine.

The side effects are –

  • headaches
  • facial flushing
  • nausea
  • hyponatremia
  • seizures

A look at the above side effects will tell a common man that there is fluid imbalance in the body that needs to be addressed urgently. Instead of fluid balance pharma cos are busy in selling their products without addressing the underlying cause.

The fluid intake of the child should be carefully looked into. Depending on the age and weight of the child you will need to come to a conclusion – whether the child is drinking enough fluids. If the bed wetting is left unaddressed in the younger days, it will result into metabolic syndrome issues later in the life. Metabolic syndrome diseases are blood pressure, blood sugar, stroke, heart diseases, respiratory organs, cold and cough and a lot more.

Bed Wetting-Side Effects-Medicines

Bed Wetting-Side Effects-Medicines

Side Effects are as under – 
Medicines prescribed by the doctors have serious side effects. You can google for every medicine prescribed for bed wetting of children. There is no logic or known reasons for prescribing the medicines.

Following medicines are prescribed –

Medicine No. 1 – DDAVP (desmopressin) – Side Effects

Headache
Nausea,
Upset stomach
Flushing of the face may occur.
Desmopressin can infrequently cause a low level of sodium in the blood, which can be serious and possibly life-threatening.
Drinking too much water or other fluids increases the risk of having a low level of sodium in the blood.
Loss of appetite
Severe nausea
Vomiting
Severe headache
Muscle weakness/spasms/cramps
Sudden weight gain
Unusual tiredness
Unusual severe drowsiness
Mental/mood changes (such as confusion, hallucinations, irritability)
Loss of consciousness, seizures, slow/shallow breathing.
What are the possible side effects of desmopressin nasal (DDAVP Nasal Spray)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using desmopressin nasal and call your doctor at once if you have any of these serious side effects:
nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable,
confusion, hallucinations, muscle pain or weakness, and/or seizure;
feeling like you might pass out;
swelling;
chest pain, fast or pounding heart rate;
vaginal pain;
nosebleed; or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears,
anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Less serious side effects may include:
runny or stuffy nose;
sore throat, cough, or other cold symptoms;
eye redness or watering;
eye itching or increased sensitivity to light;
headache, weakness;
feeling dizzy or agitated;
nausea, vomiting, stomach pain;
hot or cold feeling; or
warmth, redness, or tingly feeling in your face.

Medicine No. 2 – Tricyclic antidepressants

  • Dry mouth
  • Dry nose
  • Blurry vision
  • Lowered gastrointestinal motility
  • or constipation
  • Urinary retention
  • Cognitive and/or memory impairment
  • And increased body temperature.
  • Drowsiness
  • Anxiety
  • Emotional blunting (apathy/anhedonia)
  • Confusion
  • Restlessness
  • Dizziness
  • Akathisia
  • Hypersensitivity
  • Changes in appetite and weight
  • Sweating
  • Sexual dysfunction
  • Muscle twitches
  • Weakness
  • Nausea and vomiting
  • Hypotension
  • Tachycardia
  • And rarely, irregular heart rhythms
  • Twitching
  • Hallucinations
  • Delirium and coma are also some of the toxic effects caused by overdose.[35]
  • Rhabdomyolysis or muscle breakdown has been rarely reported with this class of drugs as
  • well
  • Discontinuation

Other two treatment options are –

Waiting and

Sound alarms to wake up the child a number of times for urination. This may interfere
with the health of child since sleeping is the most important function for young ones.